Cancer vs. Normal

Importance (MDA) Taxonomy
fit_result 22.6 NA
Otu000105 3.85 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Porphyromonadaceae(100);Porphyromonas(100);
Otu000310 3.4 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Peptostreptococcaceae(100);Peptostreptococcus(100);
Otu000281 2.32 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Clostridiales_Incertae_Sedis_XI(100);Parvimonas(100);
Otu000264 2.2 Bacteria(100);Fusobacteria(100);Fusobacteriia(100);Fusobacteriales(100);Fusobacteriaceae(100);Fusobacterium(100);
Otu000057 2.04 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Prevotellaceae(100);Prevotella(100);
Otu000356 1.33 Bacteria(100);Firmicutes(100);Bacilli(100);Bacillales(100);Bacillales_Incertae_Sedis_XI(100);Gemella(100);
Otu000029 1.24 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Ruminococcaceae(100);unclassified(91);
Otu000019 1.15 Bacteria(100);Actinobacteria(100);Actinobacteria(100);Coriobacteriales(100);Coriobacteriaceae(100);Collinsella(100);
Otu000260 1.06 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Porphyromonadaceae(100);Porphyromonas(100);
Otu000008 1.04 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);Anaerostipes(100);
Otu000097 1.02 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);Clostridium_XlVa(91);


Adenoma vs. Normal

Importance (MDA) Taxonomy
fit_result 5.38 NA
Otu000014 2.37 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(100);
Otu000011 1.73 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Ruminococcaceae(100);Ruminococcus(69);
Otu000029 1.53 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Ruminococcaceae(100);unclassified(91);
Otu000010 1.5 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);unclassified(100);unclassified(100);


Lesion vs. Normal

Importance (MDA) Taxonomy
fit_result 13.8 NA
Otu000014 2.67 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(100);
Otu000029 2.02 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Ruminococcaceae(100);unclassified(91);
Otu000003 1.86 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Bacteroidaceae(100);Bacteroides(100);
Otu000105 1.83 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Porphyromonadaceae(100);Porphyromonas(100);
Otu000011 1.81 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Ruminococcaceae(100);Ruminococcus(69);
Otu000007 1.78 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Bacteroidaceae(100);Bacteroides(100);
Otu000044 1.75 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(100);
Otu000008 1.73 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);Anaerostipes(100);
Otu000028 1.63 Bacteria(100);Proteobacteria(100);Gammaproteobacteria(100);Enterobacteriales(100);Enterobacteriaceae(100);unclassified(100);
Otu000002 1.58 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Bacteroidaceae(100);Bacteroides(100);
Otu000010 1.52 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);unclassified(100);unclassified(100);
Otu000088 1.52 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(100);
Otu000006 1.51 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Ruminococcaceae(100);Faecalibacterium(100);
Otu000060 1.5 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(100);
Otu000022 1.49 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);Blautia(100);
Otu000049 1.44 Bacteria(100);Bacteroidetes(100);Bacteroidia(100);Bacteroidales(100);Porphyromonadaceae(100);Parabacteroides(100);
Otu000009 1.38 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);Blautia(97);
Otu000013 1.34 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);Blautia(100);
Otu000020 1.33 Bacteria(100);Firmicutes(100);Bacilli(100);Lactobacillales(100);Streptococcaceae(100);Streptococcus(100);
Otu000087 1.31 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(97);
Otu000032 1.28 Bacteria(100);Firmicutes(100);Clostridia(100);Clostridiales(100);Lachnospiraceae(100);unclassified(100);

Lesion Sensitivity Cancer Sensitivity Adenoma Sensitivity Specificity Accuracy
Positive FIT 100.0 100 100.0 0.0 96.0
Negative FIT 57.9 80 53.9 78.4 67.3

Most Advanced Finding Colonoscopy RF Model FIT
Positive Results Sensitivity (95% CI) Positive Results Sensitivity (95% CI)
no. no. % no. %
Cancer 120 114 95 (90.8-98.3) 90 75 (67.5-82.5)
Advanced Adenoma 109 69 63.3 (54.1-72.5) 21 19.3 (54.1-72.5)
Nonadvanced Adenoma 89 52 58.4 (48.3-68.5) 10 11.2 (48.3-68.5)
Any Lesion 318 235 73.9 (69.2-78.9) 121 38.1 (33-43.4)
Negative Results Specificity (95% CI) Negative Results Specificity (95% CI)
Negative Colonosopies 172 131 76.2 (69.8-82.6) 167 97.1 (94.2-99.4)
Prevalence PPV NPV
RF Model FIT RF Model FIT
Cancer 0.3% 0.01185 0.07204 0.9998 0.9992
Adv. Adenoma 5.7% 0.1383 0.286 0.9717 0.9521
Nonadv. Ade. 17.7% 0.3452 0.4539 0.8949 0.8357
All Lesions 30.2% 0.5729 0.8499 0.8709 0.7837